This manual covers the complete cobas 4800 system comprised of the cobas 4800 software, the cobas x 480 instrument used for sample preparation, and the cobas z 480 analyzer used for amplification and detection using realtime pcr. The combination of the two analyzers with cobas it 3000 solution provides true operational integration for small laboratories. The system utilizes a total nucleic acid isolation sample preparation method with realtime polymerase chain reaction pcr technology for amplification and detection. Evaluation of two commercial realtime pcr assays for detection. The instrument delivers precise results for 22 parameters of high importance for bioprocess control in process development as well as in manufacturing. Jan 17, 2018 making our bcrabl portfolio compatible with the 7500 fast dx and cobas z 480 platforms will help ensure that we can serve even more patients around the world. Checkreport software pcr cycler, luminex 100200 hpv genotypes detectable by all tested methods are shown in bold. Once the thermal run is complete the asap software processes the fluorescence data using data analysis algorithms, assesses the validity of the controls and. The cobas egfr mutation test v2 is a realtime pcr test for the qualitative detection of defined mutations of the epidermal growth factor receptor egfr gene in nonsmall cell lung cancer nsclc patients. Used roche cobas 4800 pcr amplification and detection system.
A headtohead analytical comparison of cobas 4800 hpv. It was designed specifically for ivd and has high performance combined with superior. Performance of the roche cobas 4800 highrisk human. Asuragen obtains ce mark of quantidex qpcr bcrabl kits on. Limit of detection was determined by the manufacturer of each assay. Roche receives fda emergency use authorization for zika. It consists of the cobas x 480 instrument for the nucleic acid extraction sample preparation and pcr pipetting and the cobas z 480 realtime pcr analyzer. Once the thermal run is complete the asap software. Watch this video to learn how cobas clinical chemistry and immunoassay systems are built to help scale your lab.
For analysis of serum, plasma, urine, cerebrospinal fluid csf, hemolysate and whole blood. The cobas p 480 instrument is a simple and flexible standalone solution that eliminates complications associated with manual sample handling. Realtime pcr with digital data capture provides accurate qualitative results. Used abi 7500, abi quantstudio7flex and 12k, biorad cfx96.
The software is compatible with the regulations for electronic records subpart b. A comparison of the roche cobas hpv test with the hybrid. The lightcycler 480 software uses unique roche algorithms for highly accurate and robust automated data analysis. Used roche cobas 4800 pcr amplification and detection. Here, we show data from the analytical validation of the quantidex qpcr bcrabl is assay. The abi 7500 fast dx realtime pcr instrument with sds software is a realtime nucleic acid amplification and fivecolor fluorescence detection system available for in vitro diagnostic use. Manual or cobas ampliprep instrument cobas taqman 48 analyzer. Manufacturer specifications cobas taqman 48 analyzer, roche. Do you want to learn more about how the cobas 6000 analyzer series handles samples. Find out more about the cobas 4800 system, which requires minimal. The cobas z 480 analyzer automatically repeats this process for a designated number of cycles, with each cycle intended to double the amount of amplicon dna.
The cobas 4000 analyzer series include the cobas c 311 module for clinical chemistry and the cobas e 411 module for immunoassays. Blood screening virology genomicsoncology companion. Numerous accessories and consumables included see photos. The cobas p 480 instrument improves laboratory efficiency by allowing valuable technician time to be used more productively, eliminating repetitive, manual sample handling, improving workflow and reducing risk of contamination, human error and workplace injury.
Egfr tissue p1 analysis package software version 1. By accepting cookies, you understand that you are directing roche to disclose data that may include internet tracking data, cookies and the ip address you used to access this website, which may be considered personal information, to these third parties for the purposes stated above. None of the equipment posted for sale on is owned by medwow, should you have any questions regarding a specific item, please direct them to the appropriate seller by making use of the available communication channels on the items page. Manufacturers system overview the cobas 4800 system provides a platform to perform. Asuragen obtains ce mark of quantidex qpcr bcrabl kits on roche diagnostics cobas z 480 analyzer read this article along with other careers information, tips and advice on biospace. Manual cobas 4800 malware antivirus software scribd.
Manufacturer specifications cobas z 480, roche diagnostics. Making our bcrabl portfolio compatible with the 7500 fast dx and cobas z 480 platforms will help ensure that we can serve even more patients around. Cobas z 480 pcr analyzer is the latest generation of lightcycler family. Achieve process reliability and full data tracking with the intuitive software and process controls of the cobas p 480 instrument. A pool of hpv primers present in the master mix is designed to. The cobas z 480 realtime pcr analyzer has the following features. Easytolearn software that walks user through the entire setup process. How to use this manual to help you find information quickly, there is a table of contents at the beginning of. The 7500 fast dx realtime pcr instrument delivers the performance required for high.
Mutation detection is achieved through pcr analysis with the cobas z 480 analyzer. Manufacturer specifications cobas z 480, roche diagnostics please note. Performing absolute quantification analysis using the fit points method. Cobas taqman 48 analyzer specifications instrument specifications technology the cobas taqman 48 analyzer is a fully automated amplification and detection system for nucleic acids using 5 nuclease technology. Flexible system for consolidating routine and special chemistry workloads. Figure a4 cobas z 480 analyzer cobas 4800 software and control unit the cobas 4800 software runs on a dedicated control unit. Cobas taqman 48 analyzer specifications instrument specifications. Works the way you do keep pace with the changing needs of. Loading and unloading the microwell plate is the only manual intervention. Defined egfr mutations are detected using dna isolated from formalinfixed paraffinembedded tumor tissue ffpet or circulatingfree. Additionally, we present data from the initial characterization of the quantidex qpcr bcrabl minor assay used to monitor e1a2 breakpoints on the cobas z 480 analyzer, bringing a complete. In addition, roche diagnostics has commercialized the cobas 4800 system, including the cobas z 480 analyzer developed for in vitro diagnostic ivd applications, and has recently developed a userdefined workflow udf software that allows the use of the cobas z 480 analyzer as a realtime pcr instrument.
Expanding access to the quantidex qpcr bcrabl is monitoring. Sample throughput up to 300 sampleshr theoretical max test throughput theoretical max 300 testshr for photometry tests only 480 testshr for. Jan 17, 2018 austin, texas january 17, 2018 asuragen, inc. This roche hamilton cobas 4800 clinical diagnostic system, consisting of the x 480 sample prepper and z 480 analyzer, offers automated sample prep and nucleic acid purification for realtime pcr multiplex amplification and virus detection. The cobas z 480 analyzer is also available as single system and can be used for parameters in the oncology field like braf, kras and egfr. Software amplilink software is a windowsbased, liscompatible user interface that manages up to 3 cobas taqman 48 analyzers. Dieser udf kann uber ein separat durchzufuhrendes booten des pcs gestartet werden. Application use the cedex bio analyzer for fast and reliable, analysis of your bioprocess. However, roche diagnostics gmbh reserves the right to make any changes necessary. Udf software that allows the use of the cobas z 480 analyzer as a realtime. Instrumentation and software required but not provided. Jun 06, 2016 do you want to learn more about how the cobas 6000 analyzer series handles samples. The cobas z 480 analyzer is also available as single system and can be used for parameters in the.
A handheld barcode scanner is connected to the control unit. Consists of entire cobas 4800 system, including x 480 sample prep unit, z 480 analyzer, and a pc with software. Hiv, hcv a hcv gt siroka nabidka vcetne virologie, mikrobiologie, std a onkologie uzivatelem definovany udf software pro ldts hiv1 test dvoji cil. Dependable performance, dependable results the cobas hpv test runs on the advanced cobas 4800 system, which requires minimal maintenance and eliminates many manual steps for maximum lab efficiency. The cobas x 480 instrument for automatized sample preparation. Sample throughput up to 300 sampleshr theoretical max test throughput theoretical max 300 testshr for photometry tests only 480 testshr for only ise tests number of channels 4reagent slots 2. The software interpreted the results and reported negative, hpv16, hpv18, or other highriskhpvforeachsample. It enables users to quickly customize the system to meet different application requirements, from basic manual analysis, a wide choice of flexible quantification methods in line with miqe guidelines. Used a preowned and tested instrument that may show signs of wear. Cobas taqman 48 analyzer specifications instrument. The cobas z 480 analyzer automatically repeats this process for a designated number of cycles, with each cycle intended to double the. Manufacturer specifications cobas taqman 48 analyzer, roche diagnostics please note.
Cobas x 480 nucleic acid extraction sample preparation. Realtime pcr with digital data capture provides accurate qualitative results with no gray zone. Evaluation of two commercial realtime pcr assays for. Onboard capacity of 45 tests and throughput of up to 480 tests per hour. Watch this video to learn how cobas clinical chemistry and. Highperformance optics optics in the cobas z 480 analyzer are engineered to ensure dyespecific signal excitation and emission, and uniform data collection across the entire pcr plate. It was designed specifically for ivd and has high performance combined with superior fluorescent signal detection. Buy used lab equipment, used lab equipment for sale products.
Intelligent sample workflow on the cobas 6000 analyzer series. The fully automated cobas 4800 system is comprised of the cobas x 480 instrument and the cobas z 480 analyzer. The cobas 4800 system consists of the cobas x 480 instrument and the cobas z 480 analyzer. Furthermore, the cobas z 480 analyzer is manufactured and tested according to the. The cobas z 480 analyzer performed amplification and detection of hpv and bglobin internal controls. Manufacturer specifications cobas taqman 48 analyzer.